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The Welsh Ambulance Service has embarked in a trial to evaluate the safety and effectiveness of adrenaline in cardiac arrests.

The PARAMEDIC-2 trial, led by the University of Warwick, is being conducted to identify how best to treat people who have a cardiac arrest to ensure their best chance of surviving.

Adrenaline has been used as part of the standard treatment of cardiac arrests for more than 60 years, but recent studies have questioned whether this treatment is safe or harmful.

This trial will look at whether adrenaline, which can be administered during resuscitation, influences a person’s chance of survival to hospital discharge.

The Welsh Ambulance Service is one of five ambulance services in the UK taking part in the study.

Watch the Trust’s Senior Research Lead, Nigel Rees, talk about the trial in the clip below.

The trial was established after the International Liaison Committee on Resuscitation called for urgent studies to find out the effects of adrenaline in cardiac arrest.

It was reviewed and approved by the Oxford Research Ethics Committee and, like all research studies run in the NHS, is being conducted in accordance with the Research Governance Framework and relevant legislation.

Members of the public who do not wish to take part in the trial can request a stainless steel bracelet, which has the words ‘NO STUDY’ engraved on it.

Clinicians will be trained to look for these bracelets in the same way they do for other medical ID bands.

This means that, in the event that you have a cardiac arrest, you will receive treatment which may include adrenaline.

For more information in the trial, visit the University of Warwick’s website.

10 Facts about the PARAMEDIC2 Trial





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